gentoo resync : 16.01.2021

26 files changed, 93 insertions, 78 deletions

diff --git a/metadata/md5-cache/sci-chemistry/GromacsWrapper-0.8.0-r1 b/metadata/md5-cache/sci-chemistry/GromacsWrapper-0.8.0-r1
index bc3a385393c2..adad14f5a695 100644
--- a/metadata/md5-cache/sci-chemistry/GromacsWrapper-0.8.0-r1
+++ b/metadata/md5-cache/sci-chemistry/GromacsWrapper-0.8.0-r1
@@ -1,15 +1,15 @@
-BDEPEND=dev-python/six[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?] sci-libs/numkit[python_targets_python3_8(-)?,python_targets_python3_9(-)?] test? ( >=dev-python/pandas-0.17[python_targets_python3_8(-)?,python_targets_python3_9(-)?] ) test? ( dev-python/six[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?] sci-libs/numkit[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/pytest-4.5.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] ) python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+BDEPEND=dev-python/six[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] sci-libs/numkit[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] test? ( >=dev-python/pandas-0.17[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) test? ( dev-python/six[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] sci-libs/numkit[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/pytest-6.2.5-r2[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?]
 DEFINED_PHASES=compile configure install prepare test unpack
 DESCRIPTION=Python framework for Gromacs
 EAPI=7
 HOMEPAGE=https://gromacswrapper.readthedocs.io
-IUSE=test python_targets_python3_8 python_targets_python3_9
+IUSE=test python_targets_python3_8 python_targets_python3_9 python_targets_python3_10
 KEYWORDS=~amd64 ~x86
 LICENSE=GPL-3 LGPL-3
-RDEPEND=dev-python/six[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?] sci-libs/numkit[python_targets_python3_8(-)?,python_targets_python3_9(-)?] python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
-REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 )
+RDEPEND=dev-python/six[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] sci-libs/numkit[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 )
+REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 python_targets_python3_10 )
 RESTRICT=!test? ( test )
 SLOT=0
 SRC_URI=https://github.com/Becksteinlab/GromacsWrapper/archive/release-0.8.0.tar.gz -> GromacsWrapper-0.8.0.tar.gz
-_eclasses_=distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	vcs-snapshot	b1abf460a493fc59ebb25de0df3f09dd	wrapper	4251d4c84c25f59094fd557e0063a974
-_md5_=02ab15bd0be40f1104b82e10c946a29a
+_eclasses_=distutils-r1	197346452a3983cc5891d518dad6e19a	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	vcs-snapshot	b1abf460a493fc59ebb25de0df3f09dd
+_md5_=488ae7cbcc578e8701d473e8f3cc3bfe
diff --git a/metadata/md5-cache/sci-chemistry/MDAnalysis-1.0.0 b/metadata/md5-cache/sci-chemistry/MDAnalysis-1.0.0
index 4fcead12330c..d48892946ed7 100644
--- a/metadata/md5-cache/sci-chemistry/MDAnalysis-1.0.0
+++ b/metadata/md5-cache/sci-chemistry/MDAnalysis-1.0.0
@@ -1,15 +1,15 @@
-BDEPEND=>=dev-python/numpy-1.13.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/netcdf4-python[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/mock[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/duecredit[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/six-1.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] test? ( >=dev-python/numpy-1.13.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/netcdf4-python[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/mock[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/duecredit[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/six-1.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/nose-1.3.7-r4[python_targets_python3_8(-)?,python_targets_python3_9(-)?] ) python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+BDEPEND=>=dev-python/numpy-1.13.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/netcdf4-python[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/mock[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/duecredit[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/six-1.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] test? ( >=dev-python/numpy-1.13.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/netcdf4-python[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/mock[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/duecredit[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/six-1.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/nose-1.3.7-r4[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?]
 DEFINED_PHASES=compile configure install prepare test
 DESCRIPTION=A python library to analyze and manipulate molecular dynamics trajectories
 EAPI=7
 HOMEPAGE=https://www.mdanalysis.org
-IUSE=test test python_targets_python3_8 python_targets_python3_9
+IUSE=test test python_targets_python3_8 python_targets_python3_9 python_targets_python3_10
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=GPL-2
-RDEPEND=>=dev-python/numpy-1.13.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/netcdf4-python[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/mock[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/duecredit[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/six-1.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
-REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 )
+RDEPEND=>=dev-python/numpy-1.13.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/netcdf4-python[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/mock[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/duecredit[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/six-1.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 )
+REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 python_targets_python3_10 )
 RESTRICT=!test? ( test )
 SLOT=0
 SRC_URI=mirror://pypi/M/MDAnalysis/MDAnalysis-1.0.0.tar.gz
-_eclasses_=distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
-_md5_=173924a2840018a8cf103252a07a1c8d
+_eclasses_=distutils-r1	197346452a3983cc5891d518dad6e19a	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
+_md5_=e07b9d991b0ebdc5253eec932ecf80ed
diff --git a/metadata/md5-cache/sci-chemistry/MDAnalysis-2.0.0 b/metadata/md5-cache/sci-chemistry/MDAnalysis-2.0.0
index 26660b84e495..659b64a3aea0 100644
--- a/metadata/md5-cache/sci-chemistry/MDAnalysis-2.0.0
+++ b/metadata/md5-cache/sci-chemistry/MDAnalysis-2.0.0
@@ -1,4 +1,4 @@
-BDEPEND=>=dev-python/numpy-1.16.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/threadpoolctl[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] test? ( >=dev-python/numpy-1.16.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/threadpoolctl[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/nose-1.3.7-r4[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) python_targets_python3_10? ( dev-lang/python:3.10 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?]
+BDEPEND=>=dev-python/numpy-1.16.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/threadpoolctl[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] test? ( >=dev-python/numpy-1.16.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/threadpoolctl[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/nose-1.3.7-r4[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?]
 DEFINED_PHASES=compile configure install prepare test
 DESCRIPTION=A python library to analyze and manipulate molecular dynamics trajectories
 EAPI=8
@@ -6,10 +6,10 @@ HOMEPAGE=https://www.mdanalysis.org
 IUSE=test python_targets_python3_8 python_targets_python3_9 python_targets_python3_10
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=GPL-2
-RDEPEND=>=dev-python/numpy-1.16.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/threadpoolctl[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) python_targets_python3_10? ( dev-lang/python:3.10 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?]
+RDEPEND=>=dev-python/numpy-1.16.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/scipy-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=sci-biology/biopython-1.71[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/networkx-1.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/GridDataFormats-0.4.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/joblib-0.12[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/matplotlib-1.5.1[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/mmtf-python-1.0.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/tqdm-4.43.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/gsd-1.9.3[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/threadpoolctl[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 )
 REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 python_targets_python3_10 )
 RESTRICT=test !test? ( test )
 SLOT=0
 SRC_URI=mirror://pypi/M/MDAnalysis/MDAnalysis-2.0.0.tar.gz
-_eclasses_=distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
+_eclasses_=distutils-r1	197346452a3983cc5891d518dad6e19a	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
 _md5_=ee1c9d9dd59c78af672cdcd2522e7f83
diff --git a/metadata/md5-cache/sci-chemistry/Manifest.gz b/metadata/md5-cache/sci-chemistry/Manifest.gz
index 8268445f5c96..900cfb0d501f 100644
--- a/metadata/md5-cache/sci-chemistry/Manifest.gz
+++ b/metadata/md5-cache/sci-chemistry/Manifest.gz
diff --git a/metadata/md5-cache/sci-chemistry/chemex-2021.4.0_p6 b/metadata/md5-cache/sci-chemistry/chemex-2021.4.0_p6
index 9c604e9447f9..d0185f38624a 100644
--- a/metadata/md5-cache/sci-chemistry/chemex-2021.4.0_p6
+++ b/metadata/md5-cache/sci-chemistry/chemex-2021.4.0_p6
@@ -1,4 +1,4 @@
-BDEPEND=test? ( python_single_target_python3_8? ( >=dev-python/asteval-0.9.25[python_targets_python3_8(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_8(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_8(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_8(-)] >=dev-python/numpy-1.21.2[python_targets_python3_8(-)] dev-python/setuptools_scm[python_targets_python3_8(-)] >=dev-python/scipy-1.7.0[python_targets_python3_8(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_8(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_8(-)] ) python_single_target_python3_9? ( >=dev-python/asteval-0.9.25[python_targets_python3_9(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_9(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_9(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_9(-)] >=dev-python/numpy-1.21.2[python_targets_python3_9(-)] dev-python/setuptools_scm[python_targets_python3_9(-)] >=dev-python/scipy-1.7.0[python_targets_python3_9(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_9(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_9(-)] ) python_single_target_python3_10? ( >=dev-python/asteval-0.9.25[python_targets_python3_10(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_10(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_10(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_10(-)] >=dev-python/numpy-1.21.2[python_targets_python3_10(-)] dev-python/setuptools_scm[python_targets_python3_10(-)] >=dev-python/scipy-1.7.0[python_targets_python3_10(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_10(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_10(-)] ) python_single_target_python3_8? ( >=dev-python/pytest-4.5.0[python_targets_python3_8(-)] ) python_single_target_python3_9? ( >=dev-python/pytest-4.5.0[python_targets_python3_9(-)] ) python_single_target_python3_10? ( >=dev-python/pytest-4.5.0[python_targets_python3_10(-)] ) ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) python_single_target_python3_8? ( >=dev-python/pyproject2setuppy-22[python_targets_python3_8(-)] ) python_single_target_python3_9? ( >=dev-python/pyproject2setuppy-22[python_targets_python3_9(-)] ) python_single_target_python3_10? ( >=dev-python/pyproject2setuppy-22[python_targets_python3_10(-)] )
+BDEPEND=test? ( python_single_target_python3_8? ( >=dev-python/asteval-0.9.25[python_targets_python3_8(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_8(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_8(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_8(-)] >=dev-python/numpy-1.21.2[python_targets_python3_8(-)] dev-python/setuptools_scm[python_targets_python3_8(-)] >=dev-python/scipy-1.7.0[python_targets_python3_8(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_8(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_8(-)] ) python_single_target_python3_9? ( >=dev-python/asteval-0.9.25[python_targets_python3_9(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_9(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_9(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_9(-)] >=dev-python/numpy-1.21.2[python_targets_python3_9(-)] dev-python/setuptools_scm[python_targets_python3_9(-)] >=dev-python/scipy-1.7.0[python_targets_python3_9(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_9(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_9(-)] ) python_single_target_python3_10? ( >=dev-python/asteval-0.9.25[python_targets_python3_10(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_10(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_10(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_10(-)] >=dev-python/numpy-1.21.2[python_targets_python3_10(-)] dev-python/setuptools_scm[python_targets_python3_10(-)] >=dev-python/scipy-1.7.0[python_targets_python3_10(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_10(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_10(-)] ) python_single_target_python3_8? ( >=dev-python/pytest-6.2.5-r2[python_targets_python3_8(-)] ) python_single_target_python3_9? ( >=dev-python/pytest-6.2.5-r2[python_targets_python3_9(-)] ) python_single_target_python3_10? ( >=dev-python/pytest-6.2.5-r2[python_targets_python3_10(-)] ) ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) python_single_target_python3_8? ( >=dev-python/pyproject2setuppy-22[python_targets_python3_8(-)] ) python_single_target_python3_9? ( >=dev-python/pyproject2setuppy-22[python_targets_python3_9(-)] ) python_single_target_python3_10? ( >=dev-python/pyproject2setuppy-22[python_targets_python3_10(-)] )
 DEFINED_PHASES=compile configure install prepare setup test
 DEPEND=python_single_target_python3_8? ( >=dev-python/asteval-0.9.25[python_targets_python3_8(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_8(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_8(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_8(-)] >=dev-python/numpy-1.21.2[python_targets_python3_8(-)] dev-python/setuptools_scm[python_targets_python3_8(-)] >=dev-python/scipy-1.7.0[python_targets_python3_8(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_8(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_8(-)] ) python_single_target_python3_9? ( >=dev-python/asteval-0.9.25[python_targets_python3_9(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_9(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_9(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_9(-)] >=dev-python/numpy-1.21.2[python_targets_python3_9(-)] dev-python/setuptools_scm[python_targets_python3_9(-)] >=dev-python/scipy-1.7.0[python_targets_python3_9(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_9(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_9(-)] ) python_single_target_python3_10? ( >=dev-python/asteval-0.9.25[python_targets_python3_10(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_10(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_10(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_10(-)] >=dev-python/numpy-1.21.2[python_targets_python3_10(-)] dev-python/setuptools_scm[python_targets_python3_10(-)] >=dev-python/scipy-1.7.0[python_targets_python3_10(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_10(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_10(-)] )
 DESCRIPTION=Program to fit chemical exchange induced shift and relaxation data
@@ -7,10 +7,10 @@ HOMEPAGE=https://github.com/gbouvignies/chemex
 IUSE=test test python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10
 KEYWORDS=~amd64
 LICENSE=BSD
-RDEPEND=python_single_target_python3_8? ( >=dev-python/asteval-0.9.25[python_targets_python3_8(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_8(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_8(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_8(-)] >=dev-python/numpy-1.21.2[python_targets_python3_8(-)] dev-python/setuptools_scm[python_targets_python3_8(-)] >=dev-python/scipy-1.7.0[python_targets_python3_8(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_8(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_8(-)] ) python_single_target_python3_9? ( >=dev-python/asteval-0.9.25[python_targets_python3_9(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_9(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_9(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_9(-)] >=dev-python/numpy-1.21.2[python_targets_python3_9(-)] dev-python/setuptools_scm[python_targets_python3_9(-)] >=dev-python/scipy-1.7.0[python_targets_python3_9(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_9(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_9(-)] ) python_single_target_python3_10? ( >=dev-python/asteval-0.9.25[python_targets_python3_10(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_10(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_10(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_10(-)] >=dev-python/numpy-1.21.2[python_targets_python3_10(-)] dev-python/setuptools_scm[python_targets_python3_10(-)] >=dev-python/scipy-1.7.0[python_targets_python3_10(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_10(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_10(-)] ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] )
+RDEPEND=python_single_target_python3_8? ( >=dev-python/asteval-0.9.25[python_targets_python3_8(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_8(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_8(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_8(-)] >=dev-python/numpy-1.21.2[python_targets_python3_8(-)] dev-python/setuptools_scm[python_targets_python3_8(-)] >=dev-python/scipy-1.7.0[python_targets_python3_8(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_8(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_8(-)] ) python_single_target_python3_9? ( >=dev-python/asteval-0.9.25[python_targets_python3_9(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_9(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_9(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_9(-)] >=dev-python/numpy-1.21.2[python_targets_python3_9(-)] dev-python/setuptools_scm[python_targets_python3_9(-)] >=dev-python/scipy-1.7.0[python_targets_python3_9(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_9(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_9(-)] ) python_single_target_python3_10? ( >=dev-python/asteval-0.9.25[python_targets_python3_10(-)] >=dev-python/jsonschema-4.1.0[python_targets_python3_10(-)] >=dev-python/lmfit-1.0.3[python_targets_python3_10(-)] >=dev-python/matplotlib-3.4.3[python_targets_python3_10(-)] >=dev-python/numpy-1.21.2[python_targets_python3_10(-)] dev-python/setuptools_scm[python_targets_python3_10(-)] >=dev-python/scipy-1.7.0[python_targets_python3_10(-)] >=dev-python/tomlkit-0.7.2[python_targets_python3_10(-)] >=dev-python/tqdm-4.61.1[python_targets_python3_10(-)] ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 )
 REQUIRED_USE=^^ ( python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10 )
 RESTRICT=test !test? ( test )
 SLOT=0
 SRC_URI=https://github.com/gbouvignies/chemex/archive/2021.4.0-dev6.tar.gz -> chemex-2021.4.0_p6.tar.gz
-_eclasses_=distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
+_eclasses_=distutils-r1	197346452a3983cc5891d518dad6e19a	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-single-r1	9783802d3840cbbd78c02b313df760cc	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
 _md5_=e88fafb6cccdbbff67212d6d8600b15b
diff --git a/metadata/md5-cache/sci-chemistry/gromacs-2020.4-r1 b/metadata/md5-cache/sci-chemistry/gromacs-2020.4-r1
index 376de8cef9c0..6d4ce0d2ec17 100644
--- a/metadata/md5-cache/sci-chemistry/gromacs-2020.4-r1
+++ b/metadata/md5-cache/sci-chemistry/gromacs-2020.4-r1
@@ -1,4 +1,4 @@
-BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 DEFINED_PHASES=compile configure install postinst prepare pretend setup test unpack
 DESCRIPTION=The ultimate molecular dynamics simulation package
 EAPI=7
@@ -6,10 +6,10 @@ HOMEPAGE=http://www.gromacs.org/
 IUSE=X blas cuda +custom-cflags +doc build-manual double-precision +fftw +gmxapi +gmxapi-legacy +hwloc lapack +lmfit mkl mpi +offensive opencl openmp +python +single-precision test +threads +tng cpu_flags_x86_sse2 cpu_flags_x86_sse4_1 cpu_flags_x86_fma4 cpu_flags_x86_avx cpu_flags_x86_avx2 python_single_target_python3_8 python_single_target_python3_9
 KEYWORDS=amd64 arm x86 ~amd64-linux ~x86-linux ~x64-macos
 LICENSE=LGPL-2.1 UoI-NCSA !mkl? ( !fftw? ( BSD ) !blas? ( BSD ) !lapack? ( BSD ) ) cuda? ( LGPL-3 ) threads? ( BSD )
-RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( single-precision double-precision ) doc? ( !build-manual ) cuda? ( single-precision ) cuda? ( !opencl ) mkl? ( !blas !fftw !lapack ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 )
 RESTRICT=!test? ( test )
 SLOT=0/2020.4
 SRC_URI=http://ftp.gromacs.org/gromacs/gromacs-2020.4.tar.gz doc? ( https://ftp.gromacs.org/manual/manual-2020.4.pdf ) test? ( http://ftp.gromacs.org/regressiontests/regressiontests-2020.4.tar.gz )
-_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	197346452a3983cc5891d518dad6e19a	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	9783802d3840cbbd78c02b313df760cc	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=d4a1466de7b41ca68c0af3b41d41045d
diff --git a/metadata/md5-cache/sci-chemistry/gromacs-2020.6-r1 b/metadata/md5-cache/sci-chemistry/gromacs-2020.6-r1
index 8e9ac1a92a6d..36071aec4a28 100644
--- a/metadata/md5-cache/sci-chemistry/gromacs-2020.6-r1
+++ b/metadata/md5-cache/sci-chemistry/gromacs-2020.6-r1
@@ -1,4 +1,4 @@
-BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 DEFINED_PHASES=compile configure install postinst prepare pretend setup test unpack
 DESCRIPTION=The ultimate molecular dynamics simulation package
 EAPI=7
@@ -6,10 +6,10 @@ HOMEPAGE=http://www.gromacs.org/
 IUSE=X blas cuda +custom-cflags +doc build-manual double-precision +fftw +gmxapi +gmxapi-legacy +hwloc lapack +lmfit mkl mpi +offensive opencl openmp +python +single-precision test +threads +tng cpu_flags_x86_sse2 cpu_flags_x86_sse4_1 cpu_flags_x86_fma4 cpu_flags_x86_avx cpu_flags_x86_avx2 python_single_target_python3_8 python_single_target_python3_9
 KEYWORDS=~amd64 ~arm ~x86 ~amd64-linux ~x86-linux ~x64-macos
 LICENSE=LGPL-2.1 UoI-NCSA !mkl? ( !fftw? ( BSD ) !blas? ( BSD ) !lapack? ( BSD ) ) cuda? ( LGPL-3 ) threads? ( BSD )
-RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14 ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( single-precision double-precision ) doc? ( !build-manual ) cuda? ( single-precision ) cuda? ( !opencl ) mkl? ( !blas !fftw !lapack ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 )
 RESTRICT=!test? ( test )
 SLOT=0/2020.6
 SRC_URI=http://ftp.gromacs.org/gromacs/gromacs-2020.6.tar.gz doc? ( https://ftp.gromacs.org/manual/manual-2020.6.pdf ) test? ( http://ftp.gromacs.org/regressiontests/regressiontests-2020.6.tar.gz )
-_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
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 _md5_=5f578ac93f0a9afb10ead42feda2e6d3
diff --git a/metadata/md5-cache/sci-chemistry/gromacs-2021.2-r1 b/metadata/md5-cache/sci-chemistry/gromacs-2021.2-r1
index 78880dd8c0a3..eac2d0a28995 100644
--- a/metadata/md5-cache/sci-chemistry/gromacs-2021.2-r1
+++ b/metadata/md5-cache/sci-chemistry/gromacs-2021.2-r1
@@ -1,4 +1,4 @@
-BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 DEFINED_PHASES=compile configure install postinst prepare pretend setup test unpack
 DESCRIPTION=The ultimate molecular dynamics simulation package
 EAPI=7
@@ -6,10 +6,10 @@ HOMEPAGE=http://www.gromacs.org/
 IUSE=X blas cuda +custom-cflags +doc build-manual double-precision +fftw +gmxapi +gmxapi-legacy +hwloc lapack +lmfit mkl mpi +offensive opencl openmp +python +single-precision test +threads +tng cpu_flags_x86_sse2 cpu_flags_x86_sse4_1 cpu_flags_x86_fma4 cpu_flags_x86_avx cpu_flags_x86_avx2 cpu_flags_x86_avx512f cpu_flags_arm_neon python_single_target_python3_8 python_single_target_python3_9
 KEYWORDS=~amd64 ~arm ~x86 ~amd64-linux ~x86-linux ~x64-macos
 LICENSE=LGPL-2.1 UoI-NCSA !mkl? ( !fftw? ( BSD ) !blas? ( BSD ) !lapack? ( BSD ) ) cuda? ( LGPL-3 ) threads? ( BSD )
-RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( single-precision double-precision ) doc? ( !build-manual ) cuda? ( single-precision ) cuda? ( !opencl ) mkl? ( !blas !fftw !lapack ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 )
 RESTRICT=!test? ( test )
 SLOT=0/2021.2
 SRC_URI=http://ftp.gromacs.org/gromacs/gromacs-2021.2.tar.gz doc? ( https://ftp.gromacs.org/manual/manual-2021.2.pdf ) test? ( http://ftp.gromacs.org/regressiontests/regressiontests-2021.2.tar.gz )
-_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
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 _md5_=9e383793917498b18e2703d0f68181bb
diff --git a/metadata/md5-cache/sci-chemistry/gromacs-2021.3-r1 b/metadata/md5-cache/sci-chemistry/gromacs-2021.3-r1
index 2ed8e8287204..56e754cc1a99 100644
--- a/metadata/md5-cache/sci-chemistry/gromacs-2021.3-r1
+++ b/metadata/md5-cache/sci-chemistry/gromacs-2021.3-r1
@@ -1,4 +1,4 @@
-BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 DEFINED_PHASES=compile configure install postinst prepare pretend setup test unpack
 DESCRIPTION=The ultimate molecular dynamics simulation package
 EAPI=8
@@ -6,10 +6,10 @@ HOMEPAGE=http://www.gromacs.org/
 IUSE=X blas cuda +custom-cflags +doc build-manual double-precision +fftw +gmxapi +gmxapi-legacy +hwloc lapack +lmfit mkl mpi +offensive opencl openmp +python +single-precision test +threads +tng cpu_flags_x86_sse2 cpu_flags_x86_sse4_1 cpu_flags_x86_fma4 cpu_flags_x86_avx cpu_flags_x86_avx2 cpu_flags_x86_avx512f cpu_flags_arm_neon python_single_target_python3_8 python_single_target_python3_9
 KEYWORDS=amd64 arm ~x86 ~amd64-linux ~x86-linux ~x64-macos
 LICENSE=LGPL-2.1 UoI-NCSA !mkl? ( !fftw? ( BSD ) !blas? ( BSD ) !lapack? ( BSD ) ) cuda? ( LGPL-3 ) threads? ( BSD )
-RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( single-precision double-precision ) doc? ( !build-manual ) cuda? ( single-precision ) cuda? ( !opencl ) mkl? ( !blas !fftw !lapack ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 )
 RESTRICT=!test? ( test )
 SLOT=0/2021.3
 SRC_URI=http://ftp.gromacs.org/gromacs/gromacs-2021.3.tar.gz doc? ( https://ftp.gromacs.org/manual/manual-2021.3.pdf ) test? ( http://ftp.gromacs.org/regressiontests/regressiontests-2021.3.tar.gz )
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 _md5_=25e164273615d4917aaeea1c14427552
diff --git a/metadata/md5-cache/sci-chemistry/gromacs-2021.4 b/metadata/md5-cache/sci-chemistry/gromacs-2021.4
index 59a52c81f8af..45607620d10f 100644
--- a/metadata/md5-cache/sci-chemistry/gromacs-2021.4
+++ b/metadata/md5-cache/sci-chemistry/gromacs-2021.4
@@ -1,4 +1,4 @@
-BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 DEFINED_PHASES=compile configure install postinst prepare pretend setup test unpack
 DESCRIPTION=The ultimate molecular dynamics simulation package
 EAPI=8
@@ -6,10 +6,10 @@ HOMEPAGE=http://www.gromacs.org/
 IUSE=X blas cuda +custom-cflags +doc build-manual double-precision +fftw +gmxapi +gmxapi-legacy +hwloc lapack +lmfit mkl mpi +offensive opencl openmp +python +single-precision test +threads +tng cpu_flags_x86_sse2 cpu_flags_x86_sse4_1 cpu_flags_x86_fma4 cpu_flags_x86_avx cpu_flags_x86_avx2 cpu_flags_x86_avx512f cpu_flags_arm_neon python_single_target_python3_8 python_single_target_python3_9
 KEYWORDS=~amd64 ~arm ~x86 ~amd64-linux ~x86-linux ~x64-macos
 LICENSE=LGPL-2.1 UoI-NCSA !mkl? ( !fftw? ( BSD ) !blas? ( BSD ) !lapack? ( BSD ) ) cuda? ( LGPL-3 ) threads? ( BSD )
-RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( single-precision double-precision ) doc? ( !build-manual ) cuda? ( single-precision ) cuda? ( !opencl ) mkl? ( !blas !fftw !lapack ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 )
 RESTRICT=!test? ( test )
 SLOT=0/2021.4
 SRC_URI=http://ftp.gromacs.org/gromacs/gromacs-2021.4.tar.gz doc? ( https://ftp.gromacs.org/manual/manual-2021.4.pdf ) test? ( http://ftp.gromacs.org/regressiontests/regressiontests-2021.4.tar.gz )
-_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	197346452a3983cc5891d518dad6e19a	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	9783802d3840cbbd78c02b313df760cc	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=f870b7fa07548e1a61d614182f39bfd7
diff --git a/metadata/md5-cache/sci-chemistry/gromacs-2021.9999 b/metadata/md5-cache/sci-chemistry/gromacs-2021.9999
index b8a1a6f8863d..3a3e2f3730dd 100644
--- a/metadata/md5-cache/sci-chemistry/gromacs-2021.9999
+++ b/metadata/md5-cache/sci-chemistry/gromacs-2021.9999
@@ -1,4 +1,4 @@
-BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) >=dev-vcs/git-1.8.2.1[curl]
+BDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) >=dev-vcs/git-1.8.2.1[curl]
 DEFINED_PHASES=compile configure install postinst prepare pretend setup test unpack
 DESCRIPTION=The ultimate molecular dynamics simulation package
 EAPI=7
@@ -6,9 +6,9 @@ HOMEPAGE=http://www.gromacs.org/
 IUSE=X blas cuda +custom-cflags +doc build-manual double-precision +fftw +gmxapi +gmxapi-legacy +hwloc lapack +lmfit mkl mpi +offensive opencl openmp +python +single-precision test +threads +tng cpu_flags_x86_sse2 cpu_flags_x86_sse4_1 cpu_flags_x86_fma4 cpu_flags_x86_avx cpu_flags_x86_avx2 cpu_flags_x86_avx512f cpu_flags_arm_neon python_single_target_python3_8 python_single_target_python3_9
 LICENSE=LGPL-2.1 UoI-NCSA !mkl? ( !fftw? ( BSD ) !blas? ( BSD ) !lapack? ( BSD ) ) cuda? ( LGPL-3 ) threads? ( BSD )
 PROPERTIES=live
-RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) !sci-chemistry/gmxapi python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] )
+RDEPEND=X? ( x11-libs/libX11 x11-libs/libSM x11-libs/libICE ) blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) lmfit? ( sci-libs/lmfit:= ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi ) python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) !sci-chemistry/gmxapi python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( single-precision double-precision ) doc? ( !build-manual ) cuda? ( single-precision ) cuda? ( !opencl ) mkl? ( !blas !fftw !lapack ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 )
 RESTRICT=!test? ( test )
 SLOT=0/2021.9999
-_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	git-r3	cc875b0c1e9b3bdac1af0f82f3ba29da	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	197346452a3983cc5891d518dad6e19a	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	git-r3	cc875b0c1e9b3bdac1af0f82f3ba29da	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	9783802d3840cbbd78c02b313df760cc	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=2d57435e93545cedb43919d1baa7d17f
diff --git a/metadata/md5-cache/sci-chemistry/gromacs-2022.9999 b/metadata/md5-cache/sci-chemistry/gromacs-2022.9999
index 2e7ab545d2fc..b6c561d63d4b 100644
--- a/metadata/md5-cache/sci-chemistry/gromacs-2022.9999
+++ b/metadata/md5-cache/sci-chemistry/gromacs-2022.9999
@@ -1,4 +1,4 @@
-BDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/sphinx[python_targets_python3_10(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) >=dev-vcs/git-1.8.2.1[curl]
+BDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/sphinx[python_targets_python3_10(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) >=dev-vcs/git-1.8.2.1[curl]
 DEFINED_PHASES=compile configure install postinst prepare pretend setup test unpack
 DESCRIPTION=The ultimate molecular dynamics simulation package
 EAPI=8
@@ -6,9 +6,9 @@ HOMEPAGE=http://www.gromacs.org/
 IUSE=blas cuda +custom-cflags +doc build-manual double-precision +fftw +gmxapi +gmxapi-legacy +hwloc lapack mkl mpi +offensive opencl openmp +python +single-precision test +threads +tng cpu_flags_x86_sse2 cpu_flags_x86_sse4_1 cpu_flags_x86_fma4 cpu_flags_x86_avx cpu_flags_x86_avx2 cpu_flags_x86_avx512f cpu_flags_arm_neon python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10
 LICENSE=LGPL-2.1 UoI-NCSA !mkl? ( !fftw? ( BSD ) !blas? ( BSD ) !lapack? ( BSD ) ) cuda? ( LGPL-3 ) threads? ( BSD )
 PROPERTIES=live
-RDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) !sci-chemistry/gmxapi <sci-chemistry/dssp-4 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] )
+RDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) !sci-chemistry/gmxapi <sci-chemistry/dssp-4 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 )
 REQUIRED_USE=|| ( single-precision double-precision ) doc? ( !build-manual ) cuda? ( single-precision ) cuda? ( !opencl ) mkl? ( !blas !fftw !lapack ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10 ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10 )
 RESTRICT=!test? ( test )
 SLOT=0/2022.9999
-_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	flag-o-matic	d5e1306543bc457213f68bb18f830d14	git-r3	cc875b0c1e9b3bdac1af0f82f3ba29da	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	197346452a3983cc5891d518dad6e19a	flag-o-matic	d5e1306543bc457213f68bb18f830d14	git-r3	cc875b0c1e9b3bdac1af0f82f3ba29da	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	9783802d3840cbbd78c02b313df760cc	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=60a2c6523423772b4e5813588723d7b7
diff --git a/metadata/md5-cache/sci-chemistry/gromacs-2022_beta1-r2 b/metadata/md5-cache/sci-chemistry/gromacs-2022_beta1-r2
index 23fedbda22e0..c3c500c41f91 100644
--- a/metadata/md5-cache/sci-chemistry/gromacs-2022_beta1-r2
+++ b/metadata/md5-cache/sci-chemistry/gromacs-2022_beta1-r2
@@ -1,4 +1,4 @@
-BDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/sphinx[python_targets_python3_10(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] )
+BDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/sphinx[python_targets_python3_10(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 )
 DEFINED_PHASES=compile configure install postinst prepare pretend setup test unpack
 DESCRIPTION=The ultimate molecular dynamics simulation package
 EAPI=8
@@ -6,10 +6,10 @@ HOMEPAGE=http://www.gromacs.org/
 IUSE=blas cuda +custom-cflags +doc build-manual double-precision +fftw +gmxapi +gmxapi-legacy +hwloc lapack mkl mpi +offensive opencl openmp +python +single-precision test +threads +tng cpu_flags_x86_sse2 cpu_flags_x86_sse4_1 cpu_flags_x86_fma4 cpu_flags_x86_avx cpu_flags_x86_avx2 cpu_flags_x86_avx512f cpu_flags_arm_neon python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux ~x64-macos
 LICENSE=LGPL-2.1 UoI-NCSA !mkl? ( !fftw? ( BSD ) !blas? ( BSD ) !lapack? ( BSD ) ) cuda? ( LGPL-3 ) threads? ( BSD )
-RDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) !sci-chemistry/gmxapi <sci-chemistry/dssp-4 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] )
+RDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) !sci-chemistry/gmxapi <sci-chemistry/dssp-4 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 )
 REQUIRED_USE=|| ( single-precision double-precision ) doc? ( !build-manual ) cuda? ( single-precision ) cuda? ( !opencl ) mkl? ( !blas !fftw !lapack ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10 ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10 )
 RESTRICT=!test? ( test )
 SLOT=0/2022_beta1
 SRC_URI=http://ftp.gromacs.org/gromacs/gromacs-2022-beta1.tar.gz doc? ( https://ftp.gromacs.org/manual/manual-2022-beta1.pdf -> manual-2022_beta1.pdf ) test? ( http://ftp.gromacs.org/regressiontests/regressiontests-2022-beta1.tar.gz )
-_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	197346452a3983cc5891d518dad6e19a	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	9783802d3840cbbd78c02b313df760cc	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=60a2c6523423772b4e5813588723d7b7
diff --git a/metadata/md5-cache/sci-chemistry/gromacs-9999 b/metadata/md5-cache/sci-chemistry/gromacs-9999
index 9536bad3a716..dc913d95d344 100644
--- a/metadata/md5-cache/sci-chemistry/gromacs-9999
+++ b/metadata/md5-cache/sci-chemistry/gromacs-9999
@@ -1,4 +1,4 @@
-BDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/sphinx[python_targets_python3_10(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) >=dev-vcs/git-1.8.2.1[curl]
+BDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) !sci-chemistry/gmxapi virtual/pkgconfig build-manual? ( app-doc/doxygen python_single_target_python3_8? ( dev-python/sphinx[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/sphinx[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/sphinx[python_targets_python3_10(-)] ) media-gfx/mscgen media-gfx/graphviz dev-texlive/texlive-latex dev-texlive/texlive-latexextra media-gfx/imagemagick ) dev-util/ninja >=dev-util/cmake-3.20.5 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) >=dev-vcs/git-1.8.2.1[curl]
 DEFINED_PHASES=compile configure install postinst prepare pretend setup test unpack
 DESCRIPTION=The ultimate molecular dynamics simulation package
 EAPI=8
@@ -6,9 +6,9 @@ HOMEPAGE=http://www.gromacs.org/
 IUSE=blas cuda +custom-cflags +doc build-manual double-precision +fftw +gmxapi +gmxapi-legacy +hwloc lapack mkl mpi +offensive opencl openmp +python +single-precision test +threads +tng cpu_flags_x86_sse2 cpu_flags_x86_sse4_1 cpu_flags_x86_fma4 cpu_flags_x86_avx cpu_flags_x86_avx2 cpu_flags_x86_avx512f cpu_flags_arm_neon python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10
 LICENSE=LGPL-2.1 UoI-NCSA !mkl? ( !fftw? ( BSD ) !blas? ( BSD ) !lapack? ( BSD ) ) cuda? ( LGPL-3 ) threads? ( BSD )
 PROPERTIES=live
-RDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) !sci-chemistry/gmxapi <sci-chemistry/dssp-4 python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] )
+RDEPEND=blas? ( virtual/blas ) cuda? ( >=dev-util/nvidia-cuda-toolkit-6.5.14[profiler] ) opencl? ( virtual/opencl ) fftw? ( sci-libs/fftw:3.0= ) hwloc? ( sys-apps/hwloc:= ) lapack? ( virtual/lapack ) mkl? ( sci-libs/mkl ) mpi? ( virtual/mpi[cxx] ) sci-libs/lmfit:= >=dev-cpp/muParser-2.3:= python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) !sci-chemistry/gmxapi <sci-chemistry/dssp-4 python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 )
 REQUIRED_USE=|| ( single-precision double-precision ) doc? ( !build-manual ) cuda? ( single-precision ) cuda? ( !opencl ) mkl? ( !blas !fftw !lapack ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10 ) ^^ ( python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10 )
 RESTRICT=!test? ( test )
 SLOT=0/9999
-_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	flag-o-matic	d5e1306543bc457213f68bb18f830d14	git-r3	cc875b0c1e9b3bdac1af0f82f3ba29da	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=bash-completion-r1	d3a60385655d9b402be765a6de333245	cmake	11fee991ab428a3370e5c20fa8231fb6	cuda	8d9c9803e990e31a336935435383ac43	distutils-r1	197346452a3983cc5891d518dad6e19a	flag-o-matic	d5e1306543bc457213f68bb18f830d14	git-r3	cc875b0c1e9b3bdac1af0f82f3ba29da	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-single-r1	9783802d3840cbbd78c02b313df760cc	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	readme.gentoo-r1	eebd0164fe61f4f7b64a683e83fdceb1	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=60a2c6523423772b4e5813588723d7b7
diff --git a/metadata/md5-cache/sci-chemistry/mdtraj-1.9.4 b/metadata/md5-cache/sci-chemistry/mdtraj-1.9.4
index a3d8d054dbe3..0c748e5d6fc4 100644
--- a/metadata/md5-cache/sci-chemistry/mdtraj-1.9.4
+++ b/metadata/md5-cache/sci-chemistry/mdtraj-1.9.4
@@ -1,4 +1,4 @@
-BDEPEND=test? ( dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/pytest-4.5.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?] ) python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+BDEPEND=test? ( dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/pytest-6.2.5-r2[python_targets_python3_8(-)?,python_targets_python3_9(-)?] ) python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
 DEFINED_PHASES=compile configure install prepare test
 DEPEND=dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] test? ( dev-python/jupyter_client[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/nbformat[python_targets_python3_8(-)?,python_targets_python3_9(-)?] )
 DESCRIPTION=Read, write and analyze MD trajectories with only a few lines of Python code
@@ -7,10 +7,10 @@ HOMEPAGE=http://mdtraj.org
 IUSE=test python_targets_python3_8 python_targets_python3_9
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=GPL-2
-RDEPEND=dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+RDEPEND=dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 )
 RESTRICT=test
 SLOT=0
 SRC_URI=mirror://pypi/m/mdtraj/mdtraj-1.9.4.tar.gz
-_eclasses_=distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
+_eclasses_=distutils-r1	197346452a3983cc5891d518dad6e19a	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
 _md5_=dbdcffa8a3d57c4db3c130a0096698ea
diff --git a/metadata/md5-cache/sci-chemistry/mdtraj-1.9.7 b/metadata/md5-cache/sci-chemistry/mdtraj-1.9.7
index c4f61bceb45e..ce578aa5c8c5 100644
--- a/metadata/md5-cache/sci-chemistry/mdtraj-1.9.7
+++ b/metadata/md5-cache/sci-chemistry/mdtraj-1.9.7
@@ -1,4 +1,4 @@
-BDEPEND=test? ( dev-python/astunparse[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pyparsing[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/pytest-4.5.0[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) python_targets_python3_10? ( dev-lang/python:3.10 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?]
+BDEPEND=test? ( dev-python/astunparse[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pyparsing[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] >=dev-python/pytest-6.2.5-r2[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?]
 DEFINED_PHASES=compile configure install prepare test
 DEPEND=dev-python/astunparse[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pyparsing[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] test? ( dev-python/ipykernel[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/jupyter_client[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/nbformat[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] sci-libs/scikit-learn[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] )
 DESCRIPTION=Read, write and analyze MD trajectories with only a few lines of Python code
@@ -7,10 +7,10 @@ HOMEPAGE=http://mdtraj.org
 IUSE=test python_targets_python3_8 python_targets_python3_9 python_targets_python3_10
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=GPL-2
-RDEPEND=dev-python/astunparse[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pyparsing[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) python_targets_python3_10? ( dev-lang/python:3.10 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?]
+RDEPEND=dev-python/astunparse[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/astor[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pandas[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pytables[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/pyparsing[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/networkx[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 )
 REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 python_targets_python3_10 )
 RESTRICT=!test? ( test )
 SLOT=0
 SRC_URI=mirror://pypi/m/mdtraj/mdtraj-1.9.7.tar.gz
-_eclasses_=distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
+_eclasses_=distutils-r1	197346452a3983cc5891d518dad6e19a	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
 _md5_=34e3e44700bff65c157b4746eba8555a
diff --git a/metadata/md5-cache/sci-chemistry/modeller-9.25 b/metadata/md5-cache/sci-chemistry/modeller-9.25
index af988ed1665c..6f2a485a449d 100644
--- a/metadata/md5-cache/sci-chemistry/modeller-9.25
+++ b/metadata/md5-cache/sci-chemistry/modeller-9.25
@@ -1,4 +1,4 @@
-BDEPEND=python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+BDEPEND=python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 DEFINED_PHASES=compile config configure install postinst postrm prepare setup test
 DEPEND=>=dev-lang/swig-1.3
 DESCRIPTION=Homology or comparative modeling of protein three-dimensional structures
@@ -7,10 +7,10 @@ HOMEPAGE=https://salilab.org/modeller/
 IUSE=doc examples python_targets_python3_8 python_targets_python3_9
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=modeller
-RDEPEND=python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+RDEPEND=python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 )
 RESTRICT=mirror
 SLOT=0
 SRC_URI=https://salilab.org/modeller/9.25/modeller-9.25.tar.gz
-_eclasses_=distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
+_eclasses_=distutils-r1	197346452a3983cc5891d518dad6e19a	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
 _md5_=5d9975b49fae85d859bbbbd318436f17
diff --git a/metadata/md5-cache/sci-chemistry/molequeue-0.9.0-r1 b/metadata/md5-cache/sci-chemistry/molequeue-0.9.0-r1
index 79c51715d5d9..f864abac4150 100644
--- a/metadata/md5-cache/sci-chemistry/molequeue-0.9.0-r1
+++ b/metadata/md5-cache/sci-chemistry/molequeue-0.9.0-r1
@@ -1,16 +1,16 @@
 BDEPEND=doc? ( app-doc/doxygen ) dev-util/ninja >=dev-util/cmake-3.20.5 test? ( x11-base/xorg-server[xvfb] x11-apps/xhost )
 DEFINED_PHASES=compile configure install prepare test
-DEPEND=dev-qt/qtcore:5 dev-qt/qtgui:5 dev-qt/qtnetwork:5 dev-qt/qtwidgets:5 zeromq? ( python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?] net-libs/cppzmq:0= )
+DEPEND=dev-qt/qtcore:5 dev-qt/qtgui:5 dev-qt/qtnetwork:5 dev-qt/qtwidgets:5 zeromq? ( python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) net-libs/cppzmq:0= )
 DESCRIPTION=Abstract, manage and coordinate execution of tasks
 EAPI=7
 HOMEPAGE=https://www.openchemistry.org/projects/molequeue/
 IUSE=+client doc server test +zeromq python_targets_python3_8 python_targets_python3_9 test
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=BSD
-RDEPEND=dev-qt/qtcore:5 dev-qt/qtgui:5 dev-qt/qtnetwork:5 dev-qt/qtwidgets:5 zeromq? ( python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?] net-libs/cppzmq:0= )
+RDEPEND=dev-qt/qtcore:5 dev-qt/qtgui:5 dev-qt/qtnetwork:5 dev-qt/qtwidgets:5 zeromq? ( python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) net-libs/cppzmq:0= )
 REQUIRED_USE=server? ( client ) test? ( server ) zeromq? ( || ( python_targets_python3_8 python_targets_python3_9 ) )
 RESTRICT=test
 SLOT=0
 SRC_URI=https://github.com/OpenChemistry/molequeue/archive/0.9.0.tar.gz -> molequeue-0.9.0.tar.gz
-_eclasses_=cmake	11fee991ab428a3370e5c20fa8231fb6	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	virtualx	fa024aa649b6bd544144bf94893d402c	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=cmake	11fee991ab428a3370e5c20fa8231fb6	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	virtualx	fa024aa649b6bd544144bf94893d402c	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=dd52a07ec2949eea740c8d0996a84e76
diff --git a/metadata/md5-cache/sci-chemistry/nmrglue-0.7 b/metadata/md5-cache/sci-chemistry/nmrglue-0.7
index 8655f8242a59..5b76d656de62 100644
--- a/metadata/md5-cache/sci-chemistry/nmrglue-0.7
+++ b/metadata/md5-cache/sci-chemistry/nmrglue-0.7
@@ -1,4 +1,4 @@
-BDEPEND=test? ( dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/nose-1.3.7-r4[python_targets_python3_8(-)?,python_targets_python3_9(-)?] ) python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+BDEPEND=test? ( dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] >=dev-python/nose-1.3.7-r4[python_targets_python3_8(-)?,python_targets_python3_9(-)?] ) python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
 DEFINED_PHASES=compile configure install prepare test
 DEPEND=dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
 DESCRIPTION=A module for working with NMR data in Python
@@ -7,10 +7,10 @@ HOMEPAGE=https://nmrglue.com/
 IUSE=test python_targets_python3_8 python_targets_python3_9
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=BSD
-RDEPEND=dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+RDEPEND=dev-python/matplotlib[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/scipy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 )
 RESTRICT=!test? ( test )
 SLOT=0
 SRC_URI=https://github.com/jjhelmus/nmrglue/releases/download/v0.7/nmrglue-0.7.tar.gz
-_eclasses_=distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
+_eclasses_=distutils-r1	197346452a3983cc5891d518dad6e19a	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
 _md5_=197459a7eef5261de4cf3cb0315254ac
diff --git a/metadata/md5-cache/sci-chemistry/openbabel-3.1.1_p20210225 b/metadata/md5-cache/sci-chemistry/openbabel-3.1.1_p20210225
index 699b2f2b8a27..5dbf06b02075 100644
--- a/metadata/md5-cache/sci-chemistry/openbabel-3.1.1_p20210225
+++ b/metadata/md5-cache/sci-chemistry/openbabel-3.1.1_p20210225
@@ -1,16 +1,16 @@
 BDEPEND=dev-lang/perl doc? ( app-doc/doxygen dev-texlive/texlive-latex ) perl? ( >=dev-lang/swig-2 ) python? ( >=dev-lang/swig-2 ) test? ( dev-lang/python ) dev-util/ninja >=dev-util/cmake-3.20.5
 DEFINED_PHASES=compile configure install postinst postrm prepare setup test
-DEPEND=dev-cpp/eigen:3 dev-libs/libxml2:2 sys-libs/zlib:= inchi? ( sci-libs/inchi ) json? ( >=dev-libs/rapidjson-1.1.0 ) png? ( x11-libs/cairo ) python? ( python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) python_targets_python3_10? ( dev-lang/python:3.10 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) wxwidgets? ( x11-libs/wxGTK:3.0-gtk3[X] ) perl? ( dev-lang/perl )
+DEPEND=dev-cpp/eigen:3 dev-libs/libxml2:2 sys-libs/zlib:= inchi? ( sci-libs/inchi ) json? ( >=dev-libs/rapidjson-1.1.0 ) png? ( x11-libs/cairo ) python? ( python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) ) wxwidgets? ( x11-libs/wxGTK:3.0-gtk3[X] ) perl? ( dev-lang/perl )
 DESCRIPTION=Interconverts file formats used in molecular modeling
 EAPI=8
 HOMEPAGE=https://openbabel.org/
 IUSE=cpu_flags_arm_neon cpu_flags_x86_sse2 cpu_flags_x86_sse4_2 doc examples +inchi json minimal openmp perl png python test wxwidgets python_targets_python3_8 python_targets_python3_9 python_targets_python3_10
 KEYWORDS=~amd64 ~arm ~x86 ~amd64-linux ~x86-linux ~ppc-macos
 LICENSE=GPL-2
-RDEPEND=dev-cpp/eigen:3 dev-libs/libxml2:2 sys-libs/zlib:= inchi? ( sci-libs/inchi ) json? ( >=dev-libs/rapidjson-1.1.0 ) png? ( x11-libs/cairo ) python? ( python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) python_targets_python3_10? ( dev-lang/python:3.10 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) wxwidgets? ( x11-libs/wxGTK:3.0-gtk3[X] ) perl? ( dev-lang/perl:= !sci-chemistry/openbabel-perl )
+RDEPEND=dev-cpp/eigen:3 dev-libs/libxml2:2 sys-libs/zlib:= inchi? ( sci-libs/inchi ) json? ( >=dev-libs/rapidjson-1.1.0 ) png? ( x11-libs/cairo ) python? ( python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) ) wxwidgets? ( x11-libs/wxGTK:3.0-gtk3[X] ) perl? ( dev-lang/perl:= !sci-chemistry/openbabel-perl )
 REQUIRED_USE=python? ( || ( python_targets_python3_8 python_targets_python3_9 python_targets_python3_10 ) ) test? ( inchi json !minimal wxwidgets )
 RESTRICT=!test? ( test )
 SLOT=0/7.0.0
 SRC_URI=https://github.com/openbabel/openbabel/archive/08e23f39b0cc39b4eebd937a5a2ffc1a7bac3e1b.tar.gz -> openbabel-3.1.1_p20210225.tar.gz https://openbabel.org/docs/dev/_static/babel130.png -> openbabel.png http://openbabel.org/OBTitle.jpg -> openbabel.jpg
-_eclasses_=cmake	11fee991ab428a3370e5c20fa8231fb6	desktop	c0d27bf73aa08ca05b663dbd31fbef28	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	perl-functions	fea344a91ebf37efadf172c6a3de5a72	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wxwidgets	7e8a20d3bacea0e3ecf6e96fb72180aa	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=cmake	11fee991ab428a3370e5c20fa8231fb6	desktop	c0d27bf73aa08ca05b663dbd31fbef28	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	perl-functions	fea344a91ebf37efadf172c6a3de5a72	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wxwidgets	7e8a20d3bacea0e3ecf6e96fb72180aa	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=c1db8254fc197741d3851ea56e2659ef
diff --git a/metadata/md5-cache/sci-chemistry/openbabel-9999 b/metadata/md5-cache/sci-chemistry/openbabel-9999
index 3fd71c0656e6..a79df23556e6 100644
--- a/metadata/md5-cache/sci-chemistry/openbabel-9999
+++ b/metadata/md5-cache/sci-chemistry/openbabel-9999
@@ -1,16 +1,16 @@
 BDEPEND=dev-lang/perl doc? ( app-doc/doxygen dev-texlive/texlive-latex ) perl? ( >=dev-lang/swig-2 ) python? ( >=dev-lang/swig-2 ) test? ( dev-lang/python ) dev-util/ninja >=dev-util/cmake-3.20.5 >=dev-vcs/git-1.8.2.1[curl]
 DEFINED_PHASES=compile configure install postinst postrm prepare setup test unpack
-DEPEND=dev-cpp/eigen:3 dev-libs/libxml2:2 sys-libs/zlib:= inchi? ( sci-libs/inchi ) json? ( >=dev-libs/rapidjson-1.1.0 ) png? ( x11-libs/cairo ) python? ( python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) python_targets_python3_10? ( dev-lang/python:3.10 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) wxwidgets? ( x11-libs/wxGTK:3.0-gtk3[X] ) perl? ( dev-lang/perl )
+DEPEND=dev-cpp/eigen:3 dev-libs/libxml2:2 sys-libs/zlib:= inchi? ( sci-libs/inchi ) json? ( >=dev-libs/rapidjson-1.1.0 ) png? ( x11-libs/cairo ) python? ( python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) ) wxwidgets? ( x11-libs/wxGTK:3.0-gtk3[X] ) perl? ( dev-lang/perl )
 DESCRIPTION=Interconverts file formats used in molecular modeling
 EAPI=8
 HOMEPAGE=https://openbabel.org/
 IUSE=cpu_flags_arm_neon cpu_flags_x86_sse2 cpu_flags_x86_sse4_2 doc examples +inchi json minimal openmp perl png python test wxwidgets python_targets_python3_8 python_targets_python3_9 python_targets_python3_10
 LICENSE=GPL-2
 PROPERTIES=live
-RDEPEND=dev-cpp/eigen:3 dev-libs/libxml2:2 sys-libs/zlib:= inchi? ( sci-libs/inchi ) json? ( >=dev-libs/rapidjson-1.1.0 ) png? ( x11-libs/cairo ) python? ( python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) python_targets_python3_10? ( dev-lang/python:3.10 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?,python_targets_python3_10(-)?] ) wxwidgets? ( x11-libs/wxGTK:3.0-gtk3[X] ) perl? ( dev-lang/perl:= !sci-chemistry/openbabel-perl )
+RDEPEND=dev-cpp/eigen:3 dev-libs/libxml2:2 sys-libs/zlib:= inchi? ( sci-libs/inchi ) json? ( >=dev-libs/rapidjson-1.1.0 ) png? ( x11-libs/cairo ) python? ( python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_targets_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) ) wxwidgets? ( x11-libs/wxGTK:3.0-gtk3[X] ) perl? ( dev-lang/perl:= !sci-chemistry/openbabel-perl )
 REQUIRED_USE=python? ( || ( python_targets_python3_8 python_targets_python3_9 python_targets_python3_10 ) ) test? ( inchi json !minimal wxwidgets )
 RESTRICT=!test? ( test )
 SLOT=0/7.0.0
 SRC_URI=https://openbabel.org/docs/dev/_static/babel130.png -> openbabel.png http://openbabel.org/OBTitle.jpg -> openbabel.jpg
-_eclasses_=cmake	11fee991ab428a3370e5c20fa8231fb6	desktop	c0d27bf73aa08ca05b663dbd31fbef28	flag-o-matic	d5e1306543bc457213f68bb18f830d14	git-r3	cc875b0c1e9b3bdac1af0f82f3ba29da	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	perl-functions	fea344a91ebf37efadf172c6a3de5a72	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wxwidgets	7e8a20d3bacea0e3ecf6e96fb72180aa	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=cmake	11fee991ab428a3370e5c20fa8231fb6	desktop	c0d27bf73aa08ca05b663dbd31fbef28	flag-o-matic	d5e1306543bc457213f68bb18f830d14	git-r3	cc875b0c1e9b3bdac1af0f82f3ba29da	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	ninja-utils	a4dab848a4490e8e48cf0baab3e61bc2	perl-functions	fea344a91ebf37efadf172c6a3de5a72	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wxwidgets	7e8a20d3bacea0e3ecf6e96fb72180aa	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=36b243b87a68fd519b12cfd66f824eb6
diff --git a/metadata/md5-cache/sci-chemistry/propka-3.2.0 b/metadata/md5-cache/sci-chemistry/propka-3.2.0
index 7ebf9bbd0673..9152ad05c6f9 100644
--- a/metadata/md5-cache/sci-chemistry/propka-3.2.0
+++ b/metadata/md5-cache/sci-chemistry/propka-3.2.0
@@ -1,4 +1,4 @@
-BDEPEND=test? ( dev-python/numpy[python_targets_python3_8(-)?] dev-python/pandas[python_targets_python3_8(-)?] ) python_targets_python3_8? ( dev-lang/python:3.8 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?] >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?]
+BDEPEND=test? ( dev-python/numpy[python_targets_python3_8(-)?] dev-python/pandas[python_targets_python3_8(-)?] ) python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) >=dev-python/setuptools-42.0.2[python_targets_python3_8(-)?]
 DEFINED_PHASES=compile configure install prepare test
 DESCRIPTION=pKa-value prediction of ionizable groups in protein and protein-ligand complexes
 EAPI=7
@@ -6,10 +6,10 @@ HOMEPAGE=https://github.com/jensengroup/propka
 IUSE=test python_targets_python3_8
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=LGPL-2.1
-RDEPEND=dev-python/numpy[python_targets_python3_8(-)?] python_targets_python3_8? ( dev-lang/python:3.8 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?]
+RDEPEND=dev-python/numpy[python_targets_python3_8(-)?] python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 )
 REQUIRED_USE=|| ( python_targets_python3_8 )
 RESTRICT=!test? ( test )
 SLOT=0
 SRC_URI=mirror://pypi/p/propka/propka-3.2.0.tar.gz
-_eclasses_=distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
+_eclasses_=distutils-r1	197346452a3983cc5891d518dad6e19a	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8
 _md5_=bd048f5978b21207dd0a67d80964171d
diff --git a/metadata/md5-cache/sci-chemistry/pymol-2.5.0 b/metadata/md5-cache/sci-chemistry/pymol-2.5.0
index 951aee6fb518..9e611dad59e6 100644
--- a/metadata/md5-cache/sci-chemistry/pymol-2.5.0
+++ b/metadata/md5-cache/sci-chemistry/pymol-2.5.0
@@ -1,4 +1,4 @@
-BDEPEND=python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+BDEPEND=python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 DEFINED_PHASES=compile configure install postinst postrm preinst prepare test
 DEPEND=dev-libs/msgpack[cxx] dev-libs/mmtf-cpp dev-python/pyopengl[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/PyQt5[opengl,python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pmw[python_targets_python3_8(-)?,python_targets_python3_9(-)?] media-libs/freetype:2 media-libs/glew:0= media-libs/glm media-libs/libpng:0= media-video/mpeg-tools sys-libs/zlib netcdf? ( sci-libs/netcdf:0= ) dev-util/desktop-file-utils x11-misc/shared-mime-info
 DESCRIPTION=A Python-extensible molecular graphics system
@@ -7,10 +7,10 @@ HOMEPAGE=https://www.pymol.org/
 IUSE=+netcdf web python_targets_python3_8 python_targets_python3_9
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux ~x64-macos
 LICENSE=PSF-2.2
-RDEPEND=dev-libs/msgpack[cxx] dev-libs/mmtf-cpp dev-python/pyopengl[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/PyQt5[opengl,python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pmw[python_targets_python3_8(-)?,python_targets_python3_9(-)?] media-libs/freetype:2 media-libs/glew:0= media-libs/glm media-libs/libpng:0= media-video/mpeg-tools sys-libs/zlib netcdf? ( sci-libs/netcdf:0= ) sci-chemistry/chemical-mime-data python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_8(-)?,python_targets_python3_9(-)?]
+RDEPEND=dev-libs/msgpack[cxx] dev-libs/mmtf-cpp dev-python/pyopengl[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/PyQt5[opengl,python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/numpy[python_targets_python3_8(-)?,python_targets_python3_9(-)?] dev-python/pmw[python_targets_python3_8(-)?,python_targets_python3_9(-)?] media-libs/freetype:2 media-libs/glew:0= media-libs/glm media-libs/libpng:0= media-video/mpeg-tools sys-libs/zlib netcdf? ( sci-libs/netcdf:0= ) sci-chemistry/chemical-mime-data python_targets_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_targets_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 )
 REQUIRED_USE=|| ( python_targets_python3_8 python_targets_python3_9 )
 RESTRICT=mirror
 SLOT=0
 SRC_URI=https://dev.gentoo.org/~pacho/pymol/pymol-1.8.4.0.png.xz https://github.com/schrodinger/pymol-open-source/archive/v2.5.0.tar.gz -> pymol-2.5.0.tar.gz
-_eclasses_=desktop	c0d27bf73aa08ca05b663dbd31fbef28	distutils-r1	63df6e5a6bbff9ec3cf60cf7cdc94f23	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multibuild	05a584848db4901c97fcd94ae7cc3a97	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	optfeature	30ce9dec2b8943338c9b015bd32bac6a	python-r1	e574a3642f886323f18f867ecc4d91c4	python-utils-r1	a8b7938ade305f087865de7e52d079b5	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg	6024fbc93167fad782e2032933654857	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=desktop	c0d27bf73aa08ca05b663dbd31fbef28	distutils-r1	197346452a3983cc5891d518dad6e19a	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multibuild	d79bd5b4bc4edcb1f5bc19591f8d4714	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	optfeature	30ce9dec2b8943338c9b015bd32bac6a	python-r1	4c008ab1e6c02cbead059dfe8b864c26	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg	6024fbc93167fad782e2032933654857	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=c7ffea6e164d1fd0a5649c6eb3a85da0
diff --git a/metadata/md5-cache/sci-chemistry/vmd-1.9.4_alpha51 b/metadata/md5-cache/sci-chemistry/vmd-1.9.4_alpha51
index 5bb882c75063..fe771eba945a 100644
--- a/metadata/md5-cache/sci-chemistry/vmd-1.9.4_alpha51
+++ b/metadata/md5-cache/sci-chemistry/vmd-1.9.4_alpha51
@@ -1,16 +1,16 @@
 BDEPEND=virtual/pkgconfig dev-lang/swig
 DEFINED_PHASES=compile configure install nofetch postinst postrm preinst prepare setup
-DEPEND=python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_8? ( dev-python/numpy[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/numpy[python_targets_python3_9(-)] ) >=dev-lang/tk-8.6.1:0= dev-lang/perl dev-libs/expat sci-libs/netcdf:0= virtual/opengl >=x11-libs/fltk-1.1.10-r2:1 x11-libs/libXft x11-libs/libXi cuda? ( >=dev-util/nvidia-cuda-toolkit-4.2.9-r1:= ) gromacs? ( >=sci-chemistry/gromacs-5.0.4-r1:0=[tng] ) sqlite? ( dev-db/sqlite:3= ) tachyon? ( >=media-gfx/tachyon-0.99_beta6 ) xinerama? ( x11-libs/libXinerama ) dev-util/desktop-file-utils x11-misc/shared-mime-info
+DEPEND=python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_8? ( dev-python/numpy[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/numpy[python_targets_python3_9(-)] ) >=dev-lang/tk-8.6.1:0= dev-lang/perl dev-libs/expat sci-libs/netcdf:0= virtual/opengl >=x11-libs/fltk-1.1.10-r2:1 x11-libs/libXft x11-libs/libXi cuda? ( >=dev-util/nvidia-cuda-toolkit-4.2.9-r1:= ) gromacs? ( >=sci-chemistry/gromacs-5.0.4-r1:0=[tng] ) sqlite? ( dev-db/sqlite:3= ) tachyon? ( >=media-gfx/tachyon-0.99_beta6 ) xinerama? ( x11-libs/libXinerama ) dev-util/desktop-file-utils x11-misc/shared-mime-info
 DESCRIPTION=Visual Molecular Dynamics
 EAPI=7
 HOMEPAGE=http://www.ks.uiuc.edu/Research/vmd/
 IUSE=cuda gromacs msms povray sqlite tachyon xinerama python_single_target_python3_8 python_single_target_python3_9
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=vmd
-RDEPEND=python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_8? ( dev-python/numpy[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/numpy[python_targets_python3_9(-)] ) >=dev-lang/tk-8.6.1:0= dev-lang/perl dev-libs/expat sci-libs/netcdf:0= virtual/opengl >=x11-libs/fltk-1.1.10-r2:1 x11-libs/libXft x11-libs/libXi cuda? ( >=dev-util/nvidia-cuda-toolkit-4.2.9-r1:= ) gromacs? ( >=sci-chemistry/gromacs-5.0.4-r1:0=[tng] ) sqlite? ( dev-db/sqlite:3= ) tachyon? ( >=media-gfx/tachyon-0.99_beta6 ) xinerama? ( x11-libs/libXinerama ) sci-biology/stride sci-chemistry/chemical-mime-data sci-chemistry/surf x11-misc/xdg-utils x11-terms/xterm msms? ( sci-chemistry/msms-bin ) povray? ( media-gfx/povray )
+RDEPEND=python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_8? ( dev-python/numpy[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/numpy[python_targets_python3_9(-)] ) >=dev-lang/tk-8.6.1:0= dev-lang/perl dev-libs/expat sci-libs/netcdf:0= virtual/opengl >=x11-libs/fltk-1.1.10-r2:1 x11-libs/libXft x11-libs/libXi cuda? ( >=dev-util/nvidia-cuda-toolkit-4.2.9-r1:= ) gromacs? ( >=sci-chemistry/gromacs-5.0.4-r1:0=[tng] ) sqlite? ( dev-db/sqlite:3= ) tachyon? ( >=media-gfx/tachyon-0.99_beta6 ) xinerama? ( x11-libs/libXinerama ) sci-biology/stride sci-chemistry/chemical-mime-data sci-chemistry/surf x11-misc/xdg-utils x11-terms/xterm msms? ( sci-chemistry/msms-bin ) povray? ( media-gfx/povray )
 REQUIRED_USE=^^ ( python_single_target_python3_8 python_single_target_python3_9 )
 RESTRICT=fetch
 SLOT=0
 SRC_URI=vmd-1.9.4a51.src.tar.gz https://dev.gentoo.org/~pacho/vmd/vmd-1.9.4_alpha51-gentoo-patches.tar.xz
-_eclasses_=cuda	8d9c9803e990e31a336935435383ac43	desktop	c0d27bf73aa08ca05b663dbd31fbef28	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	prefix	d04f14b297013ad1410550c0757f14f8	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg	6024fbc93167fad782e2032933654857	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=cuda	8d9c9803e990e31a336935435383ac43	desktop	c0d27bf73aa08ca05b663dbd31fbef28	eapi8-dosym	cd7d420bb5be5ee079f27239ce76b8f5	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	dab5d8ec471d025b79c9e6906bcf3bff	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	prefix	d04f14b297013ad1410550c0757f14f8	python-single-r1	9783802d3840cbbd78c02b313df760cc	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	strip-linguas	ac3ee41ee2d31d8c41a77c0838320cc7	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	wrapper	4251d4c84c25f59094fd557e0063a974	xdg	6024fbc93167fad782e2032933654857	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=8b2cc7a2bd011a6f3854147562919701
diff --git a/metadata/md5-cache/sci-chemistry/vmd-1.9.4_alpha55 b/metadata/md5-cache/sci-chemistry/vmd-1.9.4_alpha55
index 36e182a8e303..90b9a9a9d305 100644
--- a/metadata/md5-cache/sci-chemistry/vmd-1.9.4_alpha55
+++ b/metadata/md5-cache/sci-chemistry/vmd-1.9.4_alpha55
@@ -1,16 +1,16 @@
 BDEPEND=virtual/pkgconfig dev-lang/swig
 DEFINED_PHASES=compile configure install nofetch postinst postrm preinst prepare setup
-DEPEND=python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) python_single_target_python3_8? ( dev-python/numpy[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/numpy[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/numpy[python_targets_python3_10(-)] ) >=dev-lang/tk-8.6.1:0= dev-lang/perl dev-libs/expat sci-libs/netcdf:0= virtual/opengl >=x11-libs/fltk-1.1.10-r2:1 x11-libs/libXft x11-libs/libXi cuda? ( >=dev-util/nvidia-cuda-toolkit-4.2.9-r1:= ) gromacs? ( >=sci-chemistry/gromacs-5.0.4-r1:0=[tng] ) sqlite? ( dev-db/sqlite:3= ) tachyon? ( >=media-gfx/tachyon-0.99_beta6 ) xinerama? ( x11-libs/libXinerama )
+DEPEND=python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) python_single_target_python3_8? ( dev-python/numpy[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/numpy[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/numpy[python_targets_python3_10(-)] ) >=dev-lang/tk-8.6.1:0= dev-lang/perl dev-libs/expat sci-libs/netcdf:0= virtual/opengl >=x11-libs/fltk-1.1.10-r2:1 x11-libs/libXft x11-libs/libXi cuda? ( >=dev-util/nvidia-cuda-toolkit-4.2.9-r1:= ) gromacs? ( >=sci-chemistry/gromacs-5.0.4-r1:0=[tng] ) sqlite? ( dev-db/sqlite:3= ) tachyon? ( >=media-gfx/tachyon-0.99_beta6 ) xinerama? ( x11-libs/libXinerama )
 DESCRIPTION=Visual Molecular Dynamics
 EAPI=8
 HOMEPAGE=http://www.ks.uiuc.edu/Research/vmd/
 IUSE=cuda gromacs msms povray sqlite tachyon xinerama python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
 LICENSE=vmd
-RDEPEND=python_single_target_python3_8? ( dev-lang/python:3.8 >=dev-lang/python-exec-2:=[python_targets_python3_8] ) python_single_target_python3_9? ( dev-lang/python:3.9 >=dev-lang/python-exec-2:=[python_targets_python3_9] ) python_single_target_python3_10? ( dev-lang/python:3.10 >=dev-lang/python-exec-2:=[python_targets_python3_10] ) python_single_target_python3_8? ( dev-python/numpy[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/numpy[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/numpy[python_targets_python3_10(-)] ) >=dev-lang/tk-8.6.1:0= dev-lang/perl dev-libs/expat sci-libs/netcdf:0= virtual/opengl >=x11-libs/fltk-1.1.10-r2:1 x11-libs/libXft x11-libs/libXi cuda? ( >=dev-util/nvidia-cuda-toolkit-4.2.9-r1:= ) gromacs? ( >=sci-chemistry/gromacs-5.0.4-r1:0=[tng] ) sqlite? ( dev-db/sqlite:3= ) tachyon? ( >=media-gfx/tachyon-0.99_beta6 ) xinerama? ( x11-libs/libXinerama ) sci-biology/stride sci-chemistry/chemical-mime-data sci-chemistry/surf x11-misc/xdg-utils x11-terms/xterm msms? ( sci-chemistry/msms-bin ) povray? ( media-gfx/povray )
+RDEPEND=python_single_target_python3_8? ( >=dev-lang/python-3.8.12_p1-r1:3.8 ) python_single_target_python3_9? ( >=dev-lang/python-3.9.9-r1:3.9 ) python_single_target_python3_10? ( >=dev-lang/python-3.10.0_p1-r1:3.10 ) python_single_target_python3_8? ( dev-python/numpy[python_targets_python3_8(-)] ) python_single_target_python3_9? ( dev-python/numpy[python_targets_python3_9(-)] ) python_single_target_python3_10? ( dev-python/numpy[python_targets_python3_10(-)] ) >=dev-lang/tk-8.6.1:0= dev-lang/perl dev-libs/expat sci-libs/netcdf:0= virtual/opengl >=x11-libs/fltk-1.1.10-r2:1 x11-libs/libXft x11-libs/libXi cuda? ( >=dev-util/nvidia-cuda-toolkit-4.2.9-r1:= ) gromacs? ( >=sci-chemistry/gromacs-5.0.4-r1:0=[tng] ) sqlite? ( dev-db/sqlite:3= ) tachyon? ( >=media-gfx/tachyon-0.99_beta6 ) xinerama? ( x11-libs/libXinerama ) sci-biology/stride sci-chemistry/chemical-mime-data sci-chemistry/surf x11-misc/xdg-utils x11-terms/xterm msms? ( sci-chemistry/msms-bin ) povray? ( media-gfx/povray )
 REQUIRED_USE=^^ ( python_single_target_python3_8 python_single_target_python3_9 python_single_target_python3_10 )
 RESTRICT=fetch
 SLOT=0
 SRC_URI=vmd-1.9.4a55.src.tar.gz fetch+https://dev.gentoo.org/~pacho/vmd/vmd-1.9.4_alpha51-gentoo-patches.tar.xz
-_eclasses_=cuda	8d9c9803e990e31a336935435383ac43	desktop	c0d27bf73aa08ca05b663dbd31fbef28	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	prefix	d04f14b297013ad1410550c0757f14f8	python-single-r1	d46c125afba8be02eb1cd7104bac6e9c	python-utils-r1	a8b7938ade305f087865de7e52d079b5	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg	6024fbc93167fad782e2032933654857	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
+_eclasses_=cuda	8d9c9803e990e31a336935435383ac43	desktop	c0d27bf73aa08ca05b663dbd31fbef28	flag-o-matic	d5e1306543bc457213f68bb18f830d14	multilib	de4beb52bfa93c4c5d96792a6b5e1784	multiprocessing	61c959fc55c15c00bbb1079d6a71370b	prefix	d04f14b297013ad1410550c0757f14f8	python-single-r1	9783802d3840cbbd78c02b313df760cc	python-utils-r1	7ec9eb6bbbeccd424c0430368962d272	toolchain-funcs	badd6e329e1f3e6bee99b35bf8763ce8	xdg	6024fbc93167fad782e2032933654857	xdg-utils	4f29a8b760a594a212abe9c2ba957c31
 _md5_=7115cb90c54b213ea4909d2b77d0f2a1
diff --git a/metadata/md5-cache/sci-chemistry/votca-2022 b/metadata/md5-cache/sci-chemistry/votca-2022
new file mode 100644
index 000000000000..5536a3742c9d
--- /dev/null
+++ b/metadata/md5-cache/sci-chemistry/votca-2022
@@ -0,0 +1,15 @@
+BDEPEND=virtual/pkgconfig dev-util/ninja >=dev-util/cmake-3.20.5
+DEFINED_PHASES=compile configure install postinst prepare test
+DEPEND=!sci-libs/votca-tools !sci-chemistry/votca-csg !sci-chemistry/votca-xtp app-shells/bash:* >=dev-cpp/eigen-3.3 dev-libs/boost:= dev-libs/expat sci-libs/fftw:3.0= dev-lang/perl gromacs? ( sci-chemistry/gromacs:= ) sci-libs/hdf5[cxx] sci-libs/libxc sci-libs/libint:2
+DESCRIPTION=Versatile Object-oriented Toolkit for Coarse-graining Applications
+EAPI=7
+HOMEPAGE=https://www.votca.org/
+IUSE=+gromacs test
+KEYWORDS=~amd64 ~x86 ~amd64-linux
+LICENSE=Apache-2.0
+RDEPEND=!sci-libs/votca-tools !sci-chemistry/votca-csg !sci-chemistry/votca-xtp app-shells/bash:* >=dev-cpp/eigen-3.3 dev-libs/boost:= dev-libs/expat sci-libs/fftw:3.0= dev-lang/perl gromacs? ( sci-chemistry/gromacs:= ) sci-libs/hdf5[cxx] sci-libs/libxc sci-libs/libint:2
+RESTRICT=!test? ( test )
+SLOT=0
+SRC_URI=https://github.com/votca/votca/archive/v2022.tar.gz -> votca-2022.tar.gz
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+_md5_=469ee285e4dd23aefc9c03eff6b6ade3